Phenotypes Associated with This Genotype

Genotype
MGI:2651823

• Allelic Composition: Lpl^tm1Sem/Lpl⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal lipid homeostasis ( J:25652 )

increased circulating cholesterol level ( J:25652 )

increased circulating HDL cholesterol level ( J:25652 )

increased circulating phospholipid level ( J:25652 )

increased circulating triglyceride level ( J:25652 )

• mild to moderate hypertriglyceridemia without affecting static HDL cholesterol levels, both with ad libitum feeding and after fasting

increased circulating VLDL triglyceride level ( J:25652 )

• triglycerides are present as very low density lipoprotein particles and chylomicrons

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
familial lipoprotein lipase deficiency		DOID:14118	OMIM:238600	J:25652