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Phenotypes Associated with This Genotype
Genotype
MGI:2652088
Allelic
Composition
Acox1tm1Jkr/Acox1tm1Jkr
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acox1tm1Jkr mutation (1 available); any Acox1 mutation (42 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Hepatocellular alterations in liver of Acox1tm1Jkr/Acox1tm1Jkr mice

cellular
• reduced numbers of round spermatids

neoplasm
• hepatic adenomas and carcinomas developed by 15 months of age, putatively due to sustained activation of Ppara
• hepatic adenomas and carcinomas developed by 15 months of age, putatively due to sustained activation of Ppara

liver/biliary system
• liver weight accounted for ~11% of total body weight compared to 4% in wild-type mice
• severe microvesicular fatty metamorphosis
• hepatic adenomas and carcinomas developed by 15 months of age, putatively due to sustained activation of Ppara
• hepatic adenomas and carcinomas developed by 15 months of age, putatively due to sustained activation of Ppara
• impaired peroxisome assembly, hepatocyte cell death followed by hepatocellular regeneration
• regenerated hepatocytes exhibited massive spontaneous peroxisome proliferation and led to a complete reversal of fatty metamorphosis by 6 to 8 months of age

homeostasis/metabolism
• accumulation of very long chain fatty acids in blood

reproductive system
• reduced numbers of spermatozoa
• reduced numbers of round spermatids

growth/size/body
• mutant mice weighed 40 to 50% less than wild-type littermates during first 5 months of age
• liver weight accounted for ~11% of total body weight compared to 4% in wild-type mice

endocrine/exocrine glands

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
peroxisomal acyl-CoA oxidase deficiency DOID:0050797 OMIM:264470
J:35794


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory