Phenotypes Associated with This Genotype

Genotype
MGI:2652447

• Allelic Composition: Tg(Thy1-APP)3Somm/0
• Genetic Background: involves: C57BL/6J * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal brain vasculature morphology ( J:67583 )

• mice exhibit aneurysm-like vasodilation unlike in wild-type mice

intracerebral hemorrhage ( J:67583 )

• mice exhibit blood vessel ruptures that range from microhemorrhages to large hematomas unlike wild-type mice

impaired blood-brain barrier function ( J:67583 )

• mice exhibit leakage in the blood-brain barrier unlike wild-type mice

microgliosis ( J:134832 )

amyloid beta deposits ( J:44603 , J:134832 )

• develop amyloid beta deposits in the neocortex and hippocampus starting at 6 months of age, which increase in size and number with age (J:44603)

• by 24 months of age, deposits occupy a substantial area of the neocortex and hippocampus and are found in the thalamus and olfactory nucleus and are isolated in the caudate putamen (J:44603)

• develop almost exclusively congophilic plaques already at their first appearance (J:44603)

• at 24 months (J:134832)

cerebral amyloid angiopathy ( J:67583 , J:134832 )

• in the neocortex, hippocampus, and thalamus and to a lesser degree in other regions such as septum, striatum, brainstem, and white matter (J:67583)

brain inflammation ( J:44603 )

• mutants exhibit inflammatory responses in the brain, showing a massive glial response

abnormal hippocampus pyramidal cell morphology ( J:44603 )

• loss of pyramidal neurons in the vicinity of amyloid beta deposits in the CA3 area

abnormal cholinergic neuron morphology ( J:44603 )

• local distortion of the cholinergic fiber network is seen in the vicinity of plaques

decreased neuron number ( J:44603 )

• local loss of neurons in the vicinity of plaques

neuron degeneration ( J:134832 )

• at 24 months

immune system

microgliosis ( J:134832 )

brain inflammation ( J:44603 )

• mutants exhibit inflammatory responses in the brain, showing a massive glial response

cardiovascular system

abnormal brain vasculature morphology ( J:67583 )

• mice exhibit aneurysm-like vasodilation unlike in wild-type mice

vascular smooth muscle hypoplasia ( J:67583 )

• mice exhibit smooth muscle cell degeneration in amyloid laden blood vessels unlike wild-type mice

abnormal blood circulation ( J:129162 )

• bicuculline-treated mice exhibit delayed and reduced amplitude of changes in cerebral blood volume compared with similarly treated wild-type mice

• at 25 months, acetazolamide-treated mice exhibit a smaller increase in the percent change of cerebral blood volume compared with similarly treated wild-type mice

intracerebral hemorrhage ( J:67583 )

• mice exhibit blood vessel ruptures that range from microhemorrhages to large hematomas unlike wild-type mice

impaired blood-brain barrier function ( J:67583 )

• mice exhibit leakage in the blood-brain barrier unlike wild-type mice

vascular inflammation ( J:67583 )

• mice exhibit cerebral amyloid angiopathy associated vasculitis unlike wild-type mice

muscle

vascular smooth muscle hypoplasia ( J:67583 )

• mice exhibit smooth muscle cell degeneration in amyloid laden blood vessels unlike wild-type mice

homeostasis/metabolism

amyloid beta deposits ( J:44603 , J:134832 )

• develop amyloid beta deposits in the neocortex and hippocampus starting at 6 months of age, which increase in size and number with age (J:44603)

• by 24 months of age, deposits occupy a substantial area of the neocortex and hippocampus and are found in the thalamus and olfactory nucleus and are isolated in the caudate putamen (J:44603)

• develop almost exclusively congophilic plaques already at their first appearance (J:44603)

• at 24 months (J:134832)

cerebral amyloid angiopathy ( J:67583 , J:134832 )

• in the neocortex, hippocampus, and thalamus and to a lesser degree in other regions such as septum, striatum, brainstem, and white matter (J:67583)

decreased physiological sensitivity to xenobiotic ( J:129162 )

• bicuculline-treated mice exhibit delayed and reduced amplitude of changes in cerebral blood volume compared with similarly treated wild-type mice

• at 25 months, acetazolamide-treated mice exhibit a smaller increase in the percent change of cerebral blood volume compared with similarly treated wild-type mice

abnormal response to injury ( J:134661 )

• during posthypoxic recovery, the spike amplitude in hippocampal region CA1 after stimulation of Schaffer collaterals in region CA3 is less than in similarly treated wild-type mice

• at 4 months, hypoxic tolerance is impaired compared to in similarly treated wild-type mice

behavior/neurological

abnormal learning/memory/conditioning ( J:134832 )

• at 6 months, mice exhibit reduced exploratory learning compared with wild-type mice

abnormal object recognition memory ( J:134832 )

• object recognition is impaired compared to in wild-type mice

hematopoietic system

microgliosis ( J:134832 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:44603
cerebral amyloid angiopathy		DOID:9246		J:67583