Phenotypes Associated with This Genotype

Genotype
MGI:2652553

• Allelic Composition: Plcb1^tm1Hssh/Plcb1^tm1Hssh
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality at weaning, incomplete penetrance ( J:43077 )

• most mice died at the age of 3 weeks

behavior/neurological

increased susceptibility to pharmacologically induced seizures ( J:43077 )

• hypersensitivity to epileptogenic drugs (metrazol and kainic acid)

convulsive seizures ( J:43077 )

• exhibited prior to 3 wks of age

• tonic-clonic or tonic extension of the whole body

• putatively evoked by hippocampal hyperexcitability

growth/size/body

decreased body size ( J:43077 )

nervous system

increased susceptibility to pharmacologically induced seizures ( J:43077 )

• hypersensitivity to epileptogenic drugs (metrazol and kainic acid)

convulsive seizures ( J:43077 )

• exhibited prior to 3 wks of age

• tonic-clonic or tonic extension of the whole body

• putatively evoked by hippocampal hyperexcitability

loss of hippocampal neurons ( J:43077 )

• loss of somatostatin-containing neurons, putatively resulting in hippocampal hyperexcitability leading to seizures

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:43077