Phenotypes Associated with This Genotype

Genotype
MGI:2652736

• Allelic Composition: Gpx1^tm1Ysh/Gpx1^tm1Ysh; Gpx2^tm2Coh/Gpx2^tm2Coh
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:71506 )

• 40% die or were euthanized due to poor health between 20-36 days of age

growth/size/body

decreased body weight ( J:71506 )

• gain weight more slowly or stop gaining weight completely starting around 16 days of age, however food intake is normal

cachexia ( J:71506 )

postnatal growth retardation ( J:71506 )

• onset of growth retardation is between 16 and 26 days of age

digestive/alimentary system

perianal ulcer ( J:71506 )

crypts of Lieberkuhn abscesses ( J:71506 )

• crypt abscesses are prevalent in the ileum, colon, and rectum

intestinal edema ( J:71506 )

• edematous colons

abnormal digestive system physiology ( J:71506 )

• anal mucus discharge

diarrhea ( J:71506 )

intestinal inflammation ( J:71506 )

• intestinal inflammation progresses from distal to proximal bowel in most homozygotes

colitis ( J:71506 )

• inflammation is limited to the mucosa

• 11 of 12 have distal colon colitis as early as 11 days of age

• 3 of 12 showed proximal colon colitis at 11-14 days of age

• most 15 day or older homozygotes have both distal and proximal colon inflammation

small intestinal inflammation ( J:71506 )

• severe inflammation of the ileum, but not jejunum or stomach , with inflammation limited to the mucosa

homeostasis/metabolism

intestinal edema ( J:71506 )

• edematous colons

decreased body temperature ( J:71506 )

• hypothermic under normal housing conditions and become even more hypothermic after being housed in metabolic cages (rest on grids without bedding for 24 hrs)

abnormal enzyme/coenzyme level ( J:71506 )

• higher levels of lipid hydroperoxide in the ileum and colon, but not jejunum

abnormal enzyme/coenzyme activity ( J:71506 )

• myeloperoxidase activity is increased in colonic mucosa

endocrine/exocrine glands

crypts of Lieberkuhn abscesses ( J:71506 )

• crypt abscesses are prevalent in the ileum, colon, and rectum

immune system

intestinal inflammation ( J:71506 )

• intestinal inflammation progresses from distal to proximal bowel in most homozygotes

colitis ( J:71506 )

• inflammation is limited to the mucosa

• 11 of 12 have distal colon colitis as early as 11 days of age

• 3 of 12 showed proximal colon colitis at 11-14 days of age

• most 15 day or older homozygotes have both distal and proximal colon inflammation

small intestinal inflammation ( J:71506 )

• severe inflammation of the ileum, but not jejunum or stomach , with inflammation limited to the mucosa

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
inflammatory bowel disease		DOID:0050589	OMIM:PS266600	J:71506