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Phenotypes Associated with This Genotype
Genotype
MGI:2653295
Allelic
Composition
Leprtm1Mgmj/Leprtm1Mgmj
Genetic
Background
B6.129-Leprtm1Mgmj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Leprtm1Mgmj mutation (1 available); any Lepr mutation (122 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• body weight is 2- to 3-fold more than in wild-type mice by 10 weeks of age
• however, body weight is 10% and 20% less in males and females, respectively, compared to Leprrdb homozygotes
• snout to anus length is increased by about 5% compared to wild-type mice

behavior/neurological

homeostasis/metabolism
• increased neointimal hyperplasia relative to Leprdb 4 weeks after femoral artery injury
• mice pair-fed with wild-type mice gain more weight and adipose tissue than wild-type mice
• increase in glucose is less than in Leprrdb homozygotes

reproductive system
• slight delay in the onset of oestrous cycling, median onset at 42 days rather than 36 days as in wild-type mice
• however, all females show signs of vaginal oestrous and no defects in ovulation are seen
• only about 40% of females are fertile

endocrine/exocrine glands
• pups born to homozygous females die within 24 h without milk in their stomachs unless fostered to wild-type mothers

cardiovascular system
• increased neointimal hyperplasia relative to Leprdb 4 weeks after femoral artery injury

integument
• pups born to homozygous females die within 24 h without milk in their stomachs unless fostered to wild-type mothers

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
obesity DOID:9970 OMIM:601665
J:82334


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory