Analysis Tools
cardiovascular system
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• by ECG telemetry, conscious homozygotes show a 14% reduction in basal heart rate variability, suggesting increased sympathetic balance
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hypotension
(
J:77732
)
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• by tail cuff manometer and arterial catheter, conscious homozygotes are hypotensive at rest, with a ~10-15 mm Hg reduction in blood pressure (8-12% of wild-type mice)
• tail cuff pressure is also reduced in a smaller cohort of homozygotes in the C57BL/6 background whereas heart rate is slightly but not significantly higher relative to wild-type mice
• no differences in body weight, heart weight, heart histology, blood chemistry, blood cell counts, cardiac output or renal function are observed
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• homozygotes are chronically hypotensive due to loss of vasoconstriction and consequent reduction of vasomotor tone
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muscle
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• homozygotes are chronically hypotensive due to loss of vasoconstriction and consequent reduction of vasomotor tone
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