hematopoietic system
small thymus
(
J:31167
)
|
• arrested B cell development after the pro-B cell stage
|
• increased numbers of myelocyte blast cells in spleen and peripheral blood
|
• increased numbers of erythroid blast cells in spleen and peripheral blood
|
• increased numbers of neutrophil blast cells in spleen and peripheral blood
|
• reduced lymphocyte numbers in the bone marrow
• decreased total peripheral blood lymphocyte number
|
• absence of NK cells
|
• increased numbers of monocytes/macrophages in spleen and peripheral blood
|
• increased numbers of monocytes/macrophages in spleen and peripheral blood
|
• reduced numbers of CD45R+/IgM+ cells
• increased numbers of F4/80+ cells
|
• increased IgM serum levels at 8 weeks, but decreased at 10-11 weeks
|
• decreased IgG and IgG3 serum levels
|
immune system
• arrested B cell development after the pro-B cell stage
|
• increased numbers of myelocyte blast cells in spleen and peripheral blood
|
• increased numbers of neutrophil blast cells in spleen and peripheral blood
|
• reduced lymphocyte numbers in the bone marrow
• decreased total peripheral blood lymphocyte number
|
• absence of NK cells
|
• increased numbers of monocytes/macrophages in spleen and peripheral blood
|
• increased numbers of monocytes/macrophages in spleen and peripheral blood
|
small thymus
(
J:31167
)
|
• reduced numbers of CD45R+/IgM+ cells
• increased numbers of F4/80+ cells
|
• small, barely detectable, peripheral lymph nodes
|
• increased IgM serum levels at 8 weeks, but decreased at 10-11 weeks
|
• decreased IgG and IgG3 serum levels
|
endocrine/exocrine glands
small thymus
(
J:31167
)
|
growth/size/body
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
NOT | combined T cell and B cell immunodeficiency | DOID:628 | J:31167 | |
NOT | X-linked severe combined immunodeficiency | DOID:0060013 |
OMIM:300400 |
J:31167 |