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Phenotypes Associated with This Genotype
Genotype
MGI:2655506
Allelic
Composition		 Hfetm2Nca/Hfetm2Nca
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hfetm2Nca mutation (1 available); any Hfe mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal iron level ( J:78536 )
• Background Sensitivity: iron loading occurred more rapidly on a 129S6/SvEvTac background than on a mixed background
decreased spleen iron level ( J:78536 )
• decreased splenic iron load

hematopoietic system
decreased spleen iron level ( J:78536 )
• decreased splenic iron load

immune system
decreased spleen iron level ( J:78536 )
• decreased splenic iron load

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
hemochromatosis type 1 DOID:0111029 OMIM:235200
 J:78536

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory