Phenotypes Associated with This Genotype

Genotype
MGI:2655804

• Allelic Composition: Mefv^tm1Chae/Mefv^tm1Chae
• Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased macrophage apoptosis ( J:82763 )

• macrophages exhibit resistance to apoptosis

increased inflammatory response ( J:82763 )

• increase in the fever response to LPS injections

increased susceptibility to endotoxin shock ( J:82763 )

• mutants are hypersensitive to endotoxin; within an hour of LPS injection, mutants become more severely hypothermic than controls and mice treated with LPS and/or D-galactosamine, a hepatocyte-sensitizing agent, show increased lethality compared to controls

homeostasis/metabolism

abnormal body temperature homeostasis ( J:82763 )

• unchallenged mutants have several-hour intervals with body temperatures greater than 39 degrees Celcius more frequently than wild type and fevers that are unpredictable

cellular

decreased macrophage apoptosis ( J:82763 )

• macrophages exhibit resistance to apoptosis

hematopoietic system

decreased macrophage apoptosis ( J:82763 )

• macrophages exhibit resistance to apoptosis

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
familial Mediterranean fever		DOID:2987	OMIM:134610 OMIM:249100	J:82763