Phenotypes Associated with This Genotype

Genotype
MGI:2657109

• Allelic Composition: Mip^Cat-Tohm/Mip^Cat-Tohm
• Genetic Background: involves: DDI

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal lens epithelium morphology ( J:82971 )

• some of the epithelial cells were multilayered, in contrast to the single layer of epithelial cells observed in wild-type lenses

abnormal lens fiber morphology ( J:82971 )

• lens fiber cells are slightly disorganized at E13.5 and the lens is disorganized and shows club-shaped and rounded fiber cells at E15.5

• lens undergoes disintegration and degeneration and has irregular arrangements of the lens fiber layers

• the nuclei of the fiber cells remain in both the anterior and posterior regions of the lenses unlike in controls in which the nuclei disappear

developmental cataract ( J:82971 )

• bilateral congenital cataracts

microphthalmia ( J:82971 )

• approximately half the weight wild-type eyes

• aside from the lens, the structure of the eye was normal

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cataract 15 multiple types		DOID:0110251	OMIM:615274	J:82971