Phenotypes Associated with This Genotype

Genotype
MGI:2657283

• Allelic Composition: Zic3^Bn/Zic3^Bn
• Genetic Background: BNT/LeJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:13124 , J:14983 )

♀ (J:13124)

♀ (J:14983)

prenatal lethality, incomplete penetrance ( J:63168 )

♀ • approximately 1/4 of animals are lost due to early lethality

craniofacial

increased cranium width ( J:5776 )

♀ • the skull is slightly wider than normal

abnormal neurocranium morphology ( J:5776 )

♀

abnormal interfrontal bone morphology ( J:5776 )

♀ • interfrontal bone is often present

cranioschisis ( J:5776 , J:63168 )

♀ • variable penetrance (J:5776)

♀ (J:63168)

growth/size/body

postnatal growth retardation ( J:63168 )

♀ • in the most severely affected animals

situs ambiguus ( J:62608 )

♀ • abnormal organ position, found in more than 50% of Bn/Y males and 38% of carrier females

limbs/digits/tail

decreased caudal vertebrae number ( J:63168 )

♀ • fewer and smaller caudal vertebrae than normal; more severe than heterozygous female

short tail ( J:13124 , J:14983 , J:62608 , J:63168 )

♀ (J:13124)

♀ (J:14983)

♀ (J:62608)

♀ (J:63168)

kinked tail ( J:13124 , J:14983 , J:62608 , J:63168 )

♀ (J:13124)

♀ (J:14983)

♀ (J:62608)

♀ (J:63168)

reproductive system

reduced fertility ( J:13124 , J:14983 , J:63168 )

♀ • number of affected offspring is lower than expected (J:13124)

♀ (J:14983)

♀ (J:63168)

skeleton

increased cranium width ( J:5776 )

♀ • the skull is slightly wider than normal

abnormal neurocranium morphology ( J:5776 )

♀

abnormal interfrontal bone morphology ( J:5776 )

♀ • interfrontal bone is often present

cranioschisis ( J:5776 , J:63168 )

♀ • variable penetrance (J:5776)

♀ (J:63168)

decreased caudal vertebrae number ( J:63168 )

♀ • fewer and smaller caudal vertebrae than normal; more severe than heterozygous female

nervous system

open neural tube ( J:5776 , J:63168 )

♀ • variable penetrance, in the sacral region; omphalocele and ventral midline closure defects noted in small numbers of embryos (J:5776)

♀ (J:63168)

exencephaly ( J:5776 , J:63168 )

♀ • variable penetrance (J:5776)

♀ (J:63168)

embryo

open neural tube ( J:5776 , J:63168 )

♀ • variable penetrance, in the sacral region; omphalocele and ventral midline closure defects noted in small numbers of embryos (J:5776)

♀ (J:63168)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
visceral heterotaxy		DOID:0050545	OMIM:306955 OMIM:605376 OMIM:606325 OMIM:613751 OMIM:614779 OMIM:PS306955	J:5776 , J:13124 , J:14983 , J:62608 , J:63168