Analysis Tools
mortality/aging
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• ~40% died within 1 to 2 days after birth
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• about 40 died within 8 to 10 days after birth
• no mice survived past 16 days of age without therapy
• mice survived up to 14 weeks on corticosteroid replacement regimen
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endocrine/exocrine glands
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• at 8 weeks (corticosteroid replacement regimen), lipid deposition had progressed but neither cholesterol crystals nor cortical hyperplasia were observed
• at 16 weeks (corticosteroid replacement regimen), lipid deposition had progressed further and cortical hyperplasia was evident
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• cortex exhibited disrupted fascicular structure
• lipid deposition in the steroidogenic compartment
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• at 16 weeks (corticosteroid replacement regimen), cortical hyperplasia was evident
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(J:43589)
(J:64337)
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• at birth and 8 weeks of age
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• at 4 and 8 weeks of age
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• at 8 weeks of age lipid deposits were evident, primarily in stromal cells
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• at 24 weeks of age ovaries were enlarged and contained few follicles
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• testes were grossly normal but showed lipid deposition within the steroidogenic interstitial region as early as E14.5
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• lipid deposition within fetal leydig cells, as early as E14.5
(J:43589)
• at 8 weeks (corticosteroid replacement regimen), lipid deposits in adult leydig cells
(J:64337)
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• evident at 8 weeks of age (corticosteroid replacement regimen)
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growth/size/body
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• at 24 weeks of age ovaries were enlarged and contained few follicles
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homeostasis/metabolism
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• in the pituitary
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reproductive system
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(J:43589)
(J:64337)
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• at birth and 8 weeks of age
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• at 4 and 8 weeks of age
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• at 8 weeks of age lipid deposits were evident, primarily in stromal cells
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• at 24 weeks of age ovaries were enlarged and contained few follicles
|
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• testes were grossly normal but showed lipid deposition within the steroidogenic interstitial region as early as E14.5
|
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• lipid deposition within fetal leydig cells, as early as E14.5
(J:43589)
• at 8 weeks (corticosteroid replacement regimen), lipid deposits in adult leydig cells
(J:64337)
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• evident at 8 weeks of age (corticosteroid replacement regimen)
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• sexually immature
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• at 4 weeks of age (corticosteroid replacement regimen), delayed germ cell maturation and increased apoptosis in developing spermatocytes
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• testes are located in the inguinal canal
(J:43589)
• testes are located in the inguinal canal
(J:64337)
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| congenital adrenal hyperplasia | DOID:0050811 |
OMIM:201710 OMIM:201810 OMIM:201910 OMIM:202010 OMIM:202110 |
J:43589 , J:55588 , J:64337 | |
