Phenotypes Associated with This Genotype

Genotype
MGI:2661963

• Allelic Composition: Insl3^tm1Par/Insl3^tm1Par
• Genetic Background: involves: 129/Sv * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal spermatid morphology ( J:55881 )

♂ • absent

multinucleated giant male germ cells ( J:55881 )

♂

reproductive system

multinucleated giant male germ cells ( J:55881 )

♂

abnormal spermatogenesis ( J:55881 )

♂ • absence of spermatids and mature sperm

abnormal spermatid morphology ( J:55881 )

♂ • absent

abnormal gubernaculum morphology ( J:55881 )

• males exhibit thin gubernacular bulbs and cords which collectively resemble the wild-type female gubernaculum

abnormal male reproductive system morphology ( J:55881 )

♂

small testis ( J:55881 )

♂ • testes were of normal size at birth but progressively degenerated

♂ • however, prostate gland morphology, seminal gland morphology, and serum testosterone levels are normal

bilateral cryptorchism ( J:55881 )

♂ • bilateral cryptorchism with testes resting adjacent to the lower pole of the kidneys

♂ • the right testicle of some males was in the contralateral position

abnormal vas deferens morphology ( J:55881 )

♂ • vas deferens were elongated

prolonged estrous cycle ( J:55881 )

♀ • prolonged cycle with each phase extended

♀ • most females had cycles exceeding 20 days

female infertility ( J:55881 )

♀ • 22% of females were infertile, however ovarian and uterine morphology was normal

♀ • fertile females gave birth to fewer litters

♀ • litters were of normal size

male infertility ( J:55881 )

♂

behavior/neurological

behavior/neurological phenotype ( J:55881 )

N • normal mounting and copulatory behavior

endocrine/exocrine glands

small testis ( J:55881 )

♂ • testes were of normal size at birth but progressively degenerated

♂ • however, prostate gland morphology, seminal gland morphology, and serum testosterone levels are normal

bilateral cryptorchism ( J:55881 )

♂ • bilateral cryptorchism with testes resting adjacent to the lower pole of the kidneys

♂ • the right testicle of some males was in the contralateral position

skeleton

abnormal gubernaculum morphology ( J:55881 )

• males exhibit thin gubernacular bulbs and cords which collectively resemble the wild-type female gubernaculum

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cryptorchidism		DOID:11383	OMIM:219050	J:55881