Phenotypes Associated with This Genotype

Genotype
MGI:2661972

• Allelic Composition: Ncf1^m1J/Ncf1^m1J
• Genetic Background: B6.Cg-Dock7^m +/+ Lepr^db/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

impaired granulocyte bactericidal activity ( J:83428 )

• peritoneal neutrophils, bone marrow cells and neutrophils isolated from bone marrow fail to produce superoxide upon stimulation in vitro with N-formyl-methionyl-leucyl-phenylalanine (fMLP) or phorbol 12-myristate 13-acetate (PMA)

abnormal macrophage physiology ( J:83428 )

• peritoneal macrophages fail to produce superoxide upon stimulation in vitro with N-formyl-methionyl-leucyl-phenylalanine (fMLP) or phorbol 12-myristate 13-acetate (PMA)

decreased susceptibility to Orthomyxoviridae infection ( J:145306 )

• following exposure to inactivated H5N1 virus , acute-lung injury is attenuated compared to in wild-type mice

hematopoietic system

impaired granulocyte bactericidal activity ( J:83428 )

• peritoneal neutrophils, bone marrow cells and neutrophils isolated from bone marrow fail to produce superoxide upon stimulation in vitro with N-formyl-methionyl-leucyl-phenylalanine (fMLP) or phorbol 12-myristate 13-acetate (PMA)

abnormal macrophage physiology ( J:83428 )

• peritoneal macrophages fail to produce superoxide upon stimulation in vitro with N-formyl-methionyl-leucyl-phenylalanine (fMLP) or phorbol 12-myristate 13-acetate (PMA)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
chronic granulomatous disease		DOID:3265	OMIM:PS306400	J:83428