Analysis Tools
behavior/neurological
| N |
• normal copulatory behavior
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cellular
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• observed at 2 weeks of age
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reproductive system
 |
• bilateral cryptorchism with testes resting high in the abdomen
• the right testicle of some males was in the contralateral position
• lack of tight attachment to the inguinal region and regression of the cranial suspensory ligament
|
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• observed at 2 weeks of age
|
|
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• absence of postmeiotic cells at 3 months of age
• surgical correction of cryptorchism rescued spermatogenesis, indicating the observed defects may be due to increased the temperature of the abdominal cavity
|
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• the gubernacular bulbs were similar to those wild-type prior to transabdominal descent of the testes (E15.5)
• the gubernacular bulbs are poorly developed relative to wild-type males and resemble those of wild-type females at E17.5
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• Mullerian duct derivatives were absent
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|
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• male infertility, however female fertility was normal as females produced litters of normal size and exhibited normal oestrus cylces
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endocrine/exocrine glands
|
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• bilateral cryptorchism with testes resting high in the abdomen
• the right testicle of some males was in the contralateral position
• lack of tight attachment to the inguinal region and regression of the cranial suspensory ligament
|
skeleton
|
• the gubernacular bulbs were similar to those wild-type prior to transabdominal descent of the testes (E15.5)
• the gubernacular bulbs are poorly developed relative to wild-type males and resemble those of wild-type females at E17.5
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| cryptorchidism | DOID:11383 |
OMIM:219050 |
J:83429 | |
