Phenotypes Associated with This Genotype

Genotype
MGI:2662270

• Allelic Composition: Slc27a4^wrfr/Slc27a4^wrfr
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Histological analysis of the Slc27a4^wrfr/Slc27a4^wrfr mouse

mortality/aging

neonatal lethality, complete penetrance ( J:83282 )

• mice died several hours after birth

behavior/neurological

absent suckling reflex ( J:83282 )

• mice failed to suckle

decreased locomotor activity ( J:83282 )

• body movements were extremely limited in mice

digestive/alimentary system

abnormal digestive system morphology ( J:83282 )

• herniated intestines observed in 10 % of mutant mice

respiratory system

abnormal respiratory system physiology ( J:83282 )

integument

sparse hair ( J:83282 )

• hair growth is impaired; compared to controls, hair growth was sparse in skin taken from E18.5 mice and grafted onto nude

decreased hair follicle number ( J:83282 )

• few developing hair follicles

shiny skin ( J:83282 )

• skin appeared abnormally shiny at birth

tight skin ( J:83282 )

• the skin mutant mice lacked the wrinkled appearance associated with normal perinatal mice

thick skin ( J:83282 )

• in newborns, epidermis was 3 times thicker than littermate controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
restrictive dermopathy		DOID:0060762	OMIM:PS275210	J:83282