Phenotypes Associated with This Genotype

Genotype
MGI:2662422

cx9

• Allelic Composition: Tg(BCL2)22Wehi/0; Tg(IghMyc)22Bri/0
• Genetic Background: involves: C57BL/6 * C57BL/6JWehi * SJL/J * SJL/JWehi

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:69571 )

• animals become terminally ill at 5-6 weeks of age

neoplasm

increased lymphoma incidence ( J:69571 )

• masses of lymphoblasts occupy the spleen, lymph nodes and thymus and extensively invade the bone marrow, liver, lungs, and kidneys, an indication of malignant lymphoma

• tumors derive from a cell with the hallmarks of a primitive hematopoietic cell

hematopoietic system

enlarged thymus ( J:69571 )

enlarged spleen ( J:69571 )

increased leukocyte cell number ( J:69571 )

• 50- to 100-fold higher levels of white blood cells compared to controls

abnormal B cell morphology ( J:69571 )

• enlarged B cells

increased B cell number ( J:69571 )

• 70% increase in numbers of B cells in bone marrow and spleen

abnormal pre-B cell morphology ( J:69571 )

• enlarged pre-B cells

increased pre-B cell number ( J:69571 )

• 30% increase in numbers of pre-B cells in bone marrow and spleen

immune system

enlarged thymus ( J:69571 )

enlarged spleen ( J:69571 )

increased leukocyte cell number ( J:69571 )

• 50- to 100-fold higher levels of white blood cells compared to controls

abnormal B cell morphology ( J:69571 )

• enlarged B cells

increased B cell number ( J:69571 )

• 70% increase in numbers of B cells in bone marrow and spleen

abnormal pre-B cell morphology ( J:69571 )

• enlarged pre-B cells

increased pre-B cell number ( J:69571 )

• 30% increase in numbers of pre-B cells in bone marrow and spleen

enlarged lymph nodes ( J:69571 )

endocrine/exocrine glands

enlarged thymus ( J:69571 )

growth/size/body

enlarged spleen ( J:69571 )