Phenotypes Associated with This Genotype

Genotype
MGI:2663794

• Allelic Composition: Gnrh1^hpg/Gnrh1^hpg
• Genetic Background: involves: 101/H * C3H/HeH

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal anogenital distance ( J:5877 )

• males exhbited a reduced distance

abnormal sex gland morphology ( J:5877 )

small seminal vesicle ( J:5877 )

♂ • arrested development

impaired ovarian folliculogenesis ( J:5877 )

♀ • though some follicles were observed in the early stages of antrum formation, most were arrested at the pre-antral phase

small ovary ( J:5877 )

♀ • arrested development

absent Leydig cells ( J:157337 )

♂

small testis ( J:5877 )

♂ • arrested development

cryptorchism ( J:5877 )

♂ • testes located in the abdomen

abnormal female reproductive system morphology ( J:5877 )

♀

small uterus ( J:5877 )

♀ • arrested development

abnormal vagina orifice morphology ( J:5877 )

♀ • failure of vagina to open fully

abnormal gametogenesis ( J:5877 )

arrest of male meiosis ( J:5877 )

♂ • rarely advanced beyond the diplotene stage

abnormal male reproductive system morphology ( J:5877 )

♂

small penis ( J:5877 )

♂

abnormal scrotum morphology ( J:5877 )

♂ • underdeveloped scrotum

endocrine/exocrine glands

abnormal sex gland morphology ( J:5877 )

small seminal vesicle ( J:5877 )

♂ • arrested development

impaired ovarian folliculogenesis ( J:5877 )

♀ • though some follicles were observed in the early stages of antrum formation, most were arrested at the pre-antral phase

small ovary ( J:5877 )

♀ • arrested development

absent Leydig cells ( J:157337 )

♂

small testis ( J:5877 )

♂ • arrested development

cryptorchism ( J:5877 )

♂ • testes located in the abdomen

abnormal pituitary gland physiology ( J:5877 )

growth/size/body

decreased body weight ( J:5877 )

• male specific decrease in body weight evident at 6 weeks of age, putatively due to testosterone deficiency

nervous system

nervous system phenotype ( J:5877 )

N • no abnormalities found

abnormal pituitary gland physiology ( J:5877 )

skeleton

skeleton phenotype ( J:5877 )

N • no craniofacial abnormalities

homeostasis/metabolism

decreased adrenocorticotropin level ( J:5877 )

• reduced levels in the pituitary in both males and females

decreased follicle stimulating hormone level ( J:5877 )

• reduced levels in the pituitary in both males and females

decreased circulating follicle stimulating hormone level ( J:5877 )

• reduced levels in both males and females

decreased luteinizing hormone level ( J:5877 )

• reduced levels in the pituitary in both males and females

decreased prolactin level ( J:5877 )

• reduced levels in the pituitary in both males and females

renal/urinary system

small penis ( J:5877 )

♂

digestive/alimentary system

abnormal anogenital distance ( J:5877 )

• males exhbited a reduced distance

integument

thin skin ( J:5877 )

cellular

arrest of male meiosis ( J:5877 )

♂ • rarely advanced beyond the diplotene stage

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hypogonadotropic hypogonadism 12 with or without anosmia		DOID:0090072	OMIM:614841	J:5877