Phenotypes Associated with This Genotype

Genotype
MGI:2664131

• Allelic Composition: Sycp3^tm1Hoog/Sycp3^tm1Hoog
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

azoospermia ( J:60153 )

♂ • spermatozoa absent from caudal epididymis

abnormal spermatocyte morphology ( J:60153 )

♂ • apoptosis of meiotic spermatocytes

arrest of male meiosis ( J:60153 )

♂ • arrest at zygotene stage of prophase I

♂ • impaired chromosomal synapsis

small seminiferous tubules ( J:60153 )

♂ • 40% reduction in diameter

decreased testis weight ( J:60153 )

♂ • 70% reduction in weight relative to wild-type

male infertility ( J:60153 )

♂

endocrine/exocrine glands

small seminiferous tubules ( J:60153 )

♂ • 40% reduction in diameter

decreased testis weight ( J:60153 )

♂ • 70% reduction in weight relative to wild-type

cellular

azoospermia ( J:60153 )

♂ • spermatozoa absent from caudal epididymis

abnormal spermatocyte morphology ( J:60153 )

♂ • apoptosis of meiotic spermatocytes

arrest of male meiosis ( J:60153 )

♂ • arrest at zygotene stage of prophase I

♂ • impaired chromosomal synapsis

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
azoospermia		DOID:14227		J:60153