Phenotypes Associated with This Genotype

Genotype
MGI:2664960

hm2

• Allelic Composition: Fcgr3^tm1Jsv/Fcgr3^tm1Jsv
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased mast cell degranulation ( J:35057 )

• peritoneal mast cells fail to degranulate when stimulated with immune complexes

impaired macrophage phagocytosis ( J:35057 )

• greatly diminished phagocytosis of IgG1 opsonized sheep red blood cells

decreased susceptibility to autoimmune hemolytic anemia ( J:83995 )

• decreased autoimmune hemolytic anemia when induced with mouse IgG2a

impaired natural killer cell mediated cytotoxicity ( J:35057 )

• lack antibody dependent NK cell mediated cytotoxicity against L1210 tumor cells

abnormal dendritic cell antigen presentation ( J:83995 )

• deficient antigen presentation by bone marrow dendritic cells

abnormal type I hypersensitivity reaction ( J:83995 )

• the systemic anaphylaxis response after passive sensitization with IgG2a is modified and partially inhibited and mortality is decreased after challenge

• antigen challenge results in an acute hypotensive effect compared to wild-type mice

decreased susceptibility to type II hypersensitivity reaction ( J:35057 )

• lack IgG dependent passive cutaneous anaphylaxis

• complement independent Arthus reaction is eliminated

hematopoietic system

decreased mast cell degranulation ( J:35057 )

• peritoneal mast cells fail to degranulate when stimulated with immune complexes

impaired macrophage phagocytosis ( J:35057 )

• greatly diminished phagocytosis of IgG1 opsonized sheep red blood cells

decreased susceptibility to autoimmune hemolytic anemia ( J:83995 )

• decreased autoimmune hemolytic anemia when induced with mouse IgG2a

impaired natural killer cell mediated cytotoxicity ( J:35057 )

• lack antibody dependent NK cell mediated cytotoxicity against L1210 tumor cells

cellular

decreased mast cell degranulation ( J:35057 )

• peritoneal mast cells fail to degranulate when stimulated with immune complexes

impaired macrophage phagocytosis ( J:35057 )

• greatly diminished phagocytosis of IgG1 opsonized sheep red blood cells