Phenotypes Associated with This Genotype

Genotype
MGI:2665106

• Allelic Composition: Pde6b^rd1-2J/Pde6b^rd1-2J
• Genetic Background: C57BL/6J-Pde6b^rd1-2J/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal retina vasculature morphology ( J:122722 )

• white retinal vessels are clinically observed at 24 days of age

retina degeneration ( J:122722 )

• indirect opthalmoscopic examination reveals a mottled retina by 24 days of age, indicative of retinal degeneration

• histological analysis demonstrates extensive degeneration of the outer nuclear layer of the retina by 16 days of age and no outer nuclear layer remaining by 30 days of age

abnormal eye electrophysiology ( J:122722 )

• electroretinogram recordings reveal that homozygotes show no detectable rod or cone responses at any age

cardiovascular system

abnormal retina vasculature morphology ( J:122722 )

• white retinal vessels are clinically observed at 24 days of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
congenital stationary night blindness autosomal dominant 2		DOID:0110863	OMIM:163500	J:82238