Phenotypes for Fmr1 MGI:2665401 MGI Mouse

behavior/neurological

• in all eye blink conditioning training session the percentage and peak amplitudes of the startle responses were higher

nervous system

abnormal neuron differentiation ( J:159211 )

• 60.4% decrease in neuronal differentiation compared with wild-type isolated adult neural progenitor/stem cells (aNPCs)

• 74.9% increase in astrocyte differentiation compared with wild-type isolated adult neural progenitor/stem cells (aNPCs)

• exogenously expressed wild-type gene, but not mutant (I304N) rescues both the neuronal and the astrocyte differentiation deficits in homozygous mutant cells

• reduced (10.4% ) neuronal differentiation but greater (75.7%) glial differentiation in aNPCs residing in the DG compared with wild-type mice

abnormal neuronal precursor proliferation ( J:159211 )

• increased proliferation of isolated aNPCs from both the forebrain and DG of adult homozygous mice

• 11% more cells in mitotic (G2/M) phase compared with wild-type controls

• increased proliferation of both stem and progenitor cells in the DG and subventricular zone of mutant mice

• normal proliferation of astrocytes in the DG of mutant mice

abnormal dentate gyrus morphology ( J:159211 )

• increased volume of the dentate gyrus (DG) in mutant mice

abnormal Purkinje cell morphology ( J:101021 )

• the percentage of single climbing fiber innervation is increased, the length of spine heads and necks is increased, and spines are more irregular

abnormal long-term depression ( J:101021 )

• induction of long term depression in Purkinje cells is significantly enhanced when stimulating parallel fibers

cellular