behavior/neurological
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• in all eye blink conditioning training session the percentage and peak amplitudes of the startle responses were higher
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nervous system
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• 60.4% decrease in neuronal differentiation compared with wild-type isolated adult neural progenitor/stem cells (aNPCs)
• 74.9% increase in astrocyte differentiation compared with wild-type isolated adult neural progenitor/stem cells (aNPCs)
• exogenously expressed wild-type gene, but not mutant (I304N) rescues both the neuronal and the astrocyte differentiation deficits in homozygous mutant cells
• reduced (10.4% ) neuronal differentiation but greater (75.7%) glial differentiation in aNPCs residing in the DG compared with wild-type mice
|
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• increased proliferation of isolated aNPCs from both the forebrain and DG of adult homozygous mice
• 11% more cells in mitotic (G2/M) phase compared with wild-type controls
• increased proliferation of both stem and progenitor cells in the DG and subventricular zone of mutant mice
• normal proliferation of astrocytes in the DG of mutant mice
|
|
• increased volume of the dentate gyrus (DG) in mutant mice
|
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• the percentage of single climbing fiber innervation is increased, the length of spine heads and necks is increased, and spines are more irregular
|
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• induction of long term depression in Purkinje cells is significantly enhanced when stimulating parallel fibers
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cellular
|
• 60.4% decrease in neuronal differentiation compared with wild-type isolated adult neural progenitor/stem cells (aNPCs)
• 74.9% increase in astrocyte differentiation compared with wild-type isolated adult neural progenitor/stem cells (aNPCs)
• exogenously expressed wild-type gene, but not mutant (I304N) rescues both the neuronal and the astrocyte differentiation deficits in homozygous mutant cells
• reduced (10.4% ) neuronal differentiation but greater (75.7%) glial differentiation in aNPCs residing in the DG compared with wild-type mice
|
|
• increased proliferation of isolated aNPCs from both the forebrain and DG of adult homozygous mice
• 11% more cells in mitotic (G2/M) phase compared with wild-type controls
• increased proliferation of both stem and progenitor cells in the DG and subventricular zone of mutant mice
• normal proliferation of astrocytes in the DG of mutant mice
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
fragile X syndrome | DOID:14261 |
OMIM:300624 |
J:101021 |