Phenotypes Associated with This Genotype

Genotype
MGI:2665504

• Allelic Composition: Apc^Min/Apc⁺
• Genetic Background: C57BL/6J-Apc^Min

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Rab25^tm1Jrgo/Rab25^tm1Jrgo Apc^Min/Apc⁺ mice exhibit increased intestinal adenoma formation compared to Apc^Min/Apc⁺ mice

mortality/aging

premature death ( J:1879 )

• average lifespan is 118 +/- 26 days

• Background Sensitivity: life span is reduced compared to mice on an (MA/MyJ x C57BL/6J-Apc)F1 or (AKR/J x C57BL/6J-Apc)F1 background

neoplasm

increased intestinal adenoma incidence ( J:1879 , J:85142 , J:158733 , J:241611 )

• develop adenomatous polyps with moderate dysplasia, mild nuclear atypia and frequent mitotic figures throughout the duodenal-to-colonic axis (J:1879)

• serotonergic cells were found in 18 of 18 adenomas (J:1879)

• most mutants exhibit a few small or medium-sized adenomas at 5 weeks of age, with numbers increasing significantly between 5 and 8 weeks and then staying at the same level thereafter (J:85142)

• mean diameter of adenomas and adenoma burden increases significantly between weeks 5 and 8 and between weeks 8 and 15 (J:85142)

• at 8 and 15 weeks of age, females have proportionally more small adenomas and fewer medium-sized adenomas than males (J:85142)

• mice fed a beef or inulin diet develop a similar number of adenomas as mice fed the rodent chow diet (J:85142)

• tubular adenomas in the intestine (J:158733)

• mice treated with a novel TNIK inhibitor NCB-0846 show reduced multiplicity and size of tumors that develop in the small intestine (J:241611)

increased colon adenoma incidence ( J:158733 , J:160399 )

• tubular adenomas in the colon (J:158733)

digestive/alimentary system

increased intestinal adenoma incidence ( J:1879 , J:85142 , J:158733 , J:241611 )

• develop adenomatous polyps with moderate dysplasia, mild nuclear atypia and frequent mitotic figures throughout the duodenal-to-colonic axis (J:1879)

• serotonergic cells were found in 18 of 18 adenomas (J:1879)

• most mutants exhibit a few small or medium-sized adenomas at 5 weeks of age, with numbers increasing significantly between 5 and 8 weeks and then staying at the same level thereafter (J:85142)

• mean diameter of adenomas and adenoma burden increases significantly between weeks 5 and 8 and between weeks 8 and 15 (J:85142)

• at 8 and 15 weeks of age, females have proportionally more small adenomas and fewer medium-sized adenomas than males (J:85142)

• mice fed a beef or inulin diet develop a similar number of adenomas as mice fed the rodent chow diet (J:85142)

• tubular adenomas in the intestine (J:158733)

• mice treated with a novel TNIK inhibitor NCB-0846 show reduced multiplicity and size of tumors that develop in the small intestine (J:241611)

increased colon adenoma incidence ( J:158733 , J:160399 )

• tubular adenomas in the colon (J:158733)

homeostasis/metabolism

increased circulating free fatty acids level ( J:86036 )

♀ • females exhibit increased free fatty acid levels at 15 weeks of age

increased circulating triglyceride level ( J:86036 )

♀ • females show increased triglyceride levels at 15 weeks of age

increased prostaglandin level ( J:85142 )

• increase in luminal prostaglandin E2 at 15 weeks of age

liver/biliary system

hepatic steatosis ( J:86036 )

• centrilobular-restricted steatosis is seen in the livers of mutants at 15 weeks of age

growth/size/body

postnatal growth retardation ( J:85142 )

♂ • regular chow-fed males stop gaining weight, lose more weight, and are smaller at 15 weeks than beef-fed males

hematopoietic system

decreased macrophage cell number ( J:85142 )

• fewer Mac-1+ (macrophages) cells in ileal mucosa at 5 weeks of age, however numbers are normal at later time points and in all dietary treatments

• however, luminal IgA, IL-12, and TNF-alpha concentrations are normal

immune system

decreased macrophage cell number ( J:85142 )

• fewer Mac-1+ (macrophages) cells in ileal mucosa at 5 weeks of age, however numbers are normal at later time points and in all dietary treatments

• however, luminal IgA, IL-12, and TNF-alpha concentrations are normal

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
colorectal cancer		DOID:9256	OMIM:114500	J:85142
familial adenomatous polyposis		DOID:0050424	OMIM:PS175100	J:86036