Phenotypes Associated with This Genotype

Genotype
MGI:2665532

cn10

• Allelic Composition: Hnf4a^tm1Sad/Hnf4a^tm1Sad; Tg(Alb1-cre)1Khk/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

abnormal liver morphology ( J:84076 )

• presence of large red lesions at 18.5 dpc

decreased liver glycogen level ( J:84076 )

• hepatic glycogen stores were 5 times lower than those of wild-type

abnormal liver development ( J:84076 )

abnormal hepatocyte morphology ( J:84076 )

• hepatocytes were small, round, and loosely associated with each other at 18.5 dpc

dissociated hepatocytes ( J:84076 )

• parenchyma was discontinuous and contained large holes that trapped numerous blood cells

homeostasis/metabolism

decreased liver glycogen level ( J:84076 )

• hepatic glycogen stores were 5 times lower than those of wild-type