Phenotypes Associated with This Genotype

Genotype
MGI:2665793

• Allelic Composition: Ar^Tfm/Y
• Genetic Background: STOCK Eda^Ta Atp7a^Mo-blo/+ +

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal anogenital distance ( J:5173 )

• indistinguishable from females

abnormal female reproductive system morphology ( J:5173 )

♀

vagina atresia ( J:5173 )

♀ • XY mice had vaginas that remained closed in most mice, though some did open at 3 months of age

abnormal gametogenesis ( J:5173 )

arrest of male meiosis ( J:5173 )

♂ • most spermatocytes were arrested at meiotic prophase, though some were observed in metaphase

abnormal male reproductive system morphology ( J:5173 )

♂

Leydig cell hypertrophy ( J:5173 )

♂ • hypertrophic

small testis ( J:5173 )

♂

cryptorchism ( J:5173 )

♂ • testes were positioned amongst fat in the abdomen

absent epididymis ( J:5173 )

♂ • the epididymides were absent from XY mice

absent vas deferens ( J:5173 )

♂ • the vas deferens were absent from XY mice

abnormal secondary sex determination ( J:5173 )

male pseudohermaphroditism ( J:5173 )

secondary sex reversal ( J:5173 )

• XY mice possessed testes and female secondary structures including vagina and teats

• XY mice did not possess ovaries

behavior/neurological

abnormal social/conspecific interaction behavior ( J:5173 )

• XY mice behaved like non-oestrus females, reduced aggression

digestive/alimentary system

abnormal anogenital distance ( J:5173 )

• indistinguishable from females

endocrine/exocrine glands

Leydig cell hypertrophy ( J:5173 )

♂ • hypertrophic

small testis ( J:5173 )

♂

cryptorchism ( J:5173 )

♂ • testes were positioned amongst fat in the abdomen

cellular

arrest of male meiosis ( J:5173 )

♂ • most spermatocytes were arrested at meiotic prophase, though some were observed in metaphase

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
androgen insensitivity syndrome		DOID:4674	OMIM:300068	J:5173