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Phenotypes Associated with This Genotype
Genotype
MGI:2668598
Allelic
Composition
Grk1tm1Citb/Grk1tm1Citb
Genetic
Background
involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grk1tm1Citb mutation (0 available); any Grk1 mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Altered morphology of Grk1tm1Citb/Grk1tm1Citb retina

vision/eye
• light-induced apoptosis of rods
• impaired rhodopsin deactivation
• rod outer segments of mice raised in 12 hour cyclic illumination are 50% shorter than those of wild-type or mutant mice raised in darkness at 6 weeks of age
• however, retinas of mutants born and raised in darkness are normal
• mutants transferred from cyclic illumination to total darkness exhibit shortening of the outer segments, but to a smaller extent than see in mutants born and raised in cyclic illumination
• when dark raised mutants are kept in continuous room light for 24 hours, retinas exhibit severe degeneration that is not observed in wild-type mice; degeneration is due to apoptosis
• flash responses of rods are greatly prolonged; the single-photon response consists of a long plateau, about 2-fold larger in amplitude than in control
• the prolonged response decays suddenly and rapidly at variable times

nervous system
• impaired rhodopsin deactivation
• rod outer segments of mice raised in 12 hour cyclic illumination are 50% shorter than those of wild-type or mutant mice raised in darkness at 6 weeks of age
• however, retinas of mutants born and raised in darkness are normal
• mutants transferred from cyclic illumination to total darkness exhibit shortening of the outer segments, but to a smaller extent than see in mutants born and raised in cyclic illumination
• when dark raised mutants are kept in continuous room light for 24 hours, retinas exhibit severe degeneration that is not observed in wild-type mice; degeneration is due to apoptosis

cellular
• light-induced apoptosis of rods

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Oguchi disease-2 DOID:0110713 OMIM:613411
J:54021


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory