Analysis Tools
mortality/aging
| N |
• unlike Prkg1tm1Hfm homozygotes, conditional mutant mice have a normal life expectancy
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nervous system
| N |
• adult conditional mutant mice display no significant differences in baseline synaptic transmission relative to control littermates
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• adult (12-14 weeks of age) but not juvenile (3-4 weeks of age) conditional mutant mice display reduced hippocampal LTP after repetitive episodes of theta burst stimulation (TBS)
• the difference in LTP between adult conditional and control mice is abolished by anisomycin (a protein synthesis inhibitor), suggesting a defect in late-phase LTP
• however, both juvenile and adult conditional mutant mice show a normal LTP in response to a single episode of tetanic stimulation, regardless of whether a weak TBS or a strong tetanic stimulus is used
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behavior/neurological
| N |
• despite a deficit in late-phase LTP, adult conditional mutant mice exhibit normal performance in hippocampus-dependent behavioral tests, i.e., contextual fear conditioning and spatial learning, with no significant differences in the freezing response to the conditioning context, in acquisition of a spatial searching strategy, or in storage and retrieval of spatial memory relative to control mice
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cardiovascular system
| N |
• unlike Prkg1tm1Hfm homozygotes, conditional mutant mice display no detectable cardiovascular abnormalities
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digestive/alimentary system
| N |
• unlike Prkg1tm1Hfm homozygotes, conditional mutant mice display no detectable gastrointestinal abnormalities
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