Phenotypes Associated with This Genotype

Genotype
MGI:2669003

• Allelic Composition: Eng^tm1Mle/Eng⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

hemorrhage ( J:58502 )

• some bleed from the nose or mouth, once or twice a week

internal hemorrhage ( J:58502 )

• two mice die with breathing difficulties and internal hemorrhages

ear telangiectasia ( J:58502 )

neck telangiectasia ( J:58502 )

• seen in some heterozygotes

tail telangiectasia ( J:58502 )

• seen in some heterozygotes

growth/size/body

weight loss ( J:58502 )

respiratory system

respiratory distress ( J:58502 )

• two mice die with breathing difficulties and internal hemorrhages

muscle

ear telangiectasia ( J:58502 )

neck telangiectasia ( J:58502 )

• seen in some heterozygotes

tail telangiectasia ( J:58502 )

• seen in some heterozygotes

integument

ruffled hair ( J:58502 )

hearing/vestibular/ear

ear telangiectasia ( J:58502 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hereditary hemorrhagic telangiectasia		DOID:1270	OMIM:187300 OMIM:600376 OMIM:601101 OMIM:615506	J:58502