Phenotypes Associated with This Genotype

Genotype
MGI:2670271

• Allelic Composition: Ro60^tm1Woln/Ro60^tm1Woln
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Glomerulonephritis in Ro60^tm1Woln/Ro60^tm1Woln mice

mortality/aging

premature death ( J:84627 )

• Background Sensitivity: approximately 28% mortality within 12 months of age, mixed genetic background involving 129S1/Sv and C57BL/6 but not when backcrossed to C57BL/6 background for 3 generations

renal/urinary system

glomerulonephritis ( J:84627 )

• membranoproliferative glomerulonephritis observed in mice on mixed genetic background involving 129S1/Sv and C57BL/6 and in mice that had been backcrossed to C57BL/6 background for 3 generations

immune system

increased IgG2a level ( J:84627 )

• 29-fold increase in unimmunized 8-week old mutants

increased IgM level ( J:84627 )

• 1.5-fold increase in in unimmunized 8-week old mutants

increased anti-nuclear antigen antibody level ( J:84627 )

• anti-chromatin and anti-ribosome antibodies were detected on mixed genetic background involving 129S1/Sv and C57BL/6 and in mice that had been backcrossed to C57BL/6 background for 3 generations

increased anti-chromatin antibody level ( J:84627 )

increased anti-double stranded DNA antibody level ( J:84627 )

increased anti-histone antibody level ( J:84627 )

increased anti-single stranded DNA antibody level ( J:84627 )

glomerulonephritis ( J:84627 )

• membranoproliferative glomerulonephritis observed in mice on mixed genetic background involving 129S1/Sv and C57BL/6 and in mice that had been backcrossed to C57BL/6 background for 3 generations

integument

integument phenotype ( J:84627 )

N • Background Sensitivity: keratinocytes from mice on a mixed 129S1/Sv and C57BL/6 background show similiar sensitivity to UVB exposure as wild-type mice compared to mutants backcrossed to C57BL/6 for 6 generations which show increased apoptosis

hematopoietic system

increased IgG2a level ( J:84627 )

• 29-fold increase in unimmunized 8-week old mutants

increased IgM level ( J:84627 )

• 1.5-fold increase in in unimmunized 8-week old mutants

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
systemic lupus erythematosus		DOID:9074	OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420	J:84627