Phenotypes Associated with This Genotype

Genotype
MGI:2670272

• Allelic Composition: Ro60^tm1Woln/Ro60⁺
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased IgG2a level ( J:84627 )

• 3-fold increase in unimmunized 8-week old mutants

increased anti-nuclear antigen antibody level ( J:84627 )

• anti-chromatin and anti-ribosome antibodies were detected on mixed genetic background involving 129S1/Sv and C57BL/6 and in mice that had been backcrossed to C57BL/6 background for 3 generations

hematopoietic system

increased IgG2a level ( J:84627 )

• 3-fold increase in unimmunized 8-week old mutants

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
systemic lupus erythematosus		DOID:9074	OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420	J:84627