Phenotypes Associated with This Genotype

Genotype
MGI:2670276

• Allelic Composition: Ro60^tm1Woln/Ro60^tm1Woln
• Genetic Background: B6.129S1-Ro60^tm1Woln

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

increased cellular sensitivity to ultraviolet irradiation ( J:84627 )

• Background Sensitivity: significant increase in the number of apoptotic keratinocyte after exposure to UVB

integument

skin photosensitivity ( J:84627 )

• Background Sensitivity: significant increase in the number of apoptotic keratinocyte after exposure to UVB, observed in mice that had been backcrossed to the C57BL/6 genetic background for 6 generations but not in mice that were on a mixed genetic background involving 129S1/Sv

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
systemic lupus erythematosus		DOID:9074	OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420	J:84627