Phenotypes Associated with This Genotype

Genotype
MGI:2670755

• Allelic Composition: Ywhae^tm1Awb/Ywhae^tm1Awb
• Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * NIH Black Swiss)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:84075 )

• most homozygotes died at birth

• 2.5% on mixed background survived

• 1% on inbred background survived

• survivors small but otherwise normal

nervous system

decreased neuronal migration ( J:84075 )

• neuronal migration distances for brain neurons are shorter than in wild-type

abnormal brain morphology ( J:84075 )

• increased apoptosis

• ventricular zone proliferation is normal

abnormal hippocampus pyramidal cell layer ( J:84075 )

• pyramidal cell layer is disorganized and less cellular

abnormal cerebral cortex morphology ( J:84075 )

• cortex is thinner than normal

cellular

decreased neuronal migration ( J:84075 )

• neuronal migration distances for brain neurons are shorter than in wild-type

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Miller-Dieker lissencephaly syndrome		DOID:0060469	OMIM:247200	J:84075