Phenotypes Associated with This Genotype

Genotype
MGI:2672009

hm1

• Allelic Composition: Etv4^tm1Arbr/Etv4^tm1Arbr
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal innervation pattern to muscle ( J:78717 )

• at E12.5 in motor neurons that normally express Etv4 axons project caudally but fail to invade the target muscles (latissimus dorsi and cutaneous maximus) and fail to branch normally within the muscles

• at E16.5 severely impaired motor neuron branching is seen in the distal portion of the latissimus dorsi

• at P14 in the latissimus dorsi, only a single nerve branch extends beyond the proximal synaptic zone and this fails to extend distally beyond the intermediate zone

abnormal motor neuron morphology ( J:78717 )

• at E11.5, LacZ+ motor neurons are located in a more dorsal position at the C7/8 of the spinal cord and this dorsal shift becomes more severe from E12.5 to E17.5

• at E11.5 the normal tight clustering of Isl1+/LacZ+ neurons in the lateral motor column is disrupted

abnormal motor neuron innervation pattern ( J:78717 )

• at E12.5 in motor neurons that normally express Etv4 axons project caudally but fail to invade the target muscles (latissimus dorsi and cutaneous maximus) and fail to branch normally within the muscles

• at E16.5 severely impaired motor neuron branching is seen in the distal portion of the latissimus dorsi

• at P14 in the latissimus dorsi, only a single nerve branch extends beyond the proximal synaptic zone and this fails to extend distally beyond the intermediate zone

• motor neurons that do not normally express Etv4 show normal innervation

decreased motor neuron number ( J:78717 )

• at E13.5 in the lateral motor column a 30% and 80% decrease is detected in the numbers of Isl1+/HB9+ and LacZ+ neurons, respectively, without any increase in apoptosis

abnormal somatic sensory system morphology ( J:107207 )

• the interosseous nerve is present but thinner than in wild-type mice

decreased pacinian corpuscle number ( J:107207 )

• 25% decrease in pacinian corpuscle numbers in the crus at P0-P1

small pacinian corpuscles ( J:107207 )

• remaining corpuscles are smaller than wild-type but structurally similar

renal/urinary system

renal hypoplasia ( J:155594 )

• in 9% of mice

absent kidney ( J:155594 )

• in 2% of mice

behavior/neurological

impaired limb coordination ( J:78717 )

• subtle defect in forelimb coordination