Phenotypes Associated with This Genotype

Genotype
MGI:2672029

• Allelic Composition: Gp1ba^tm1Ware/Gp1ba^tm1Ware
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Transmission electron microscopy of mature megakaryocytes from Gp1ba^tm1Ware/Gp1ba^tm1Ware mice

homeostasis/metabolism

increased bleeding time ( J:63389 )

• tail bleeding times greater than ten minutes as compared to 3 minutes for controls

hematopoietic system

abnormal megakaryocyte differentiation ( J:63389 )

• megakaryocytes lack "developing platelet fields"

• demarcating platelet membranes are either vacuolated or disordered

thrombocytopenia ( J:63389 )

giant platelets ( J:63389 )

• giant platelets found in the peripheral blood

cellular

abnormal megakaryocyte differentiation ( J:63389 )

• megakaryocytes lack "developing platelet fields"

• demarcating platelet membranes are either vacuolated or disordered

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Bernard-Soulier syndrome		DOID:2217	OMIM:231200	J:63389