Phenotypes Associated with This Genotype

Genotype
MGI:2672991

• Allelic Composition: Kera^tm1Cyl/Kera^tm1Cyl
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal iridocorneal angle ( J:83873 )

• the cornea-iris angle of the anterior segment was 30-40% narrower

decreased cornea thickness ( J:128992 )

abnormal cornea stroma morphology ( J:83873 )

• corneal stroma was 40 % thinner than wild-type

• collagen fibrils were larger with circular profiles

• anterior fibril diameters were 30.7 nm as opposed to 26.6

• posterior fibril diameters were 32 nm as opposed to 26.9

• fibril packing was less regular

immune system

decreased neutrophil cell number ( J:128992 )

• the number of neutrophils in LPS-treated corneas is decreased compared to in similarly treated wild-type mice

• however, CXC chemokine production is normal

abnormal inflammatory response ( J:128992 )

• following lethal irradiation and transplantation of EGFP+ cells, infiltration of bone marrow-derived inflammatory cells into LPS treated corneas is reduced compared to in similarly treated wild-type mice

hematopoietic system

decreased neutrophil cell number ( J:128992 )

• the number of neutrophils in LPS-treated corneas is decreased compared to in similarly treated wild-type mice

• however, CXC chemokine production is normal

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cornea plana		DOID:0060287	OMIM:121400 OMIM:217300	J:83873