Phenotypes Associated with This Genotype

Genotype
MGI:2673460

• Allelic Composition: Fancd2^tm1Hou/Fancd2^tm1Hou
• Genetic Background: 129S4/SvJae-Fancd2^tm1Hou

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased adenoma incidence ( J:84892 )

• observed in both on a 129S4/SvJae genetic background and on a background involving both 129S4/SvJae and C57BL/6J

increased carcinoma incidence ( J:84892 )

• observed in both on a 129S4/SvJae genetic background and on a background involving both 129S4/SvJae and C57BL/6J

cellular

oligozoospermia ( J:84892 )

♂

abnormal spermatocyte morphology ( J:84892 )

♂ • apoptotic pachytene spermatocytes observed in some seminiferous tubules

abnormal male meiosis ( J:84892 )

♂ • increased frequency of synaptic abnormalities beginning in mid-zygotene

endocrine/exocrine glands

abnormal ovarian follicle number ( J:84892 )

♀ • reduced number of developing follicles

abnormal seminiferous tubule morphology ( J:84892 )

♂ • incomplete penetrance of abnormal tubules either lacking germ cells or containing apoptotic spermatocytes

small testis ( J:84892 )

♂

reproductive system

oligozoospermia ( J:84892 )

♂

abnormal spermatocyte morphology ( J:84892 )

♂ • apoptotic pachytene spermatocytes observed in some seminiferous tubules

abnormal male meiosis ( J:84892 )

♂ • increased frequency of synaptic abnormalities beginning in mid-zygotene

abnormal ovarian follicle number ( J:84892 )

♀ • reduced number of developing follicles

abnormal seminiferous tubule morphology ( J:84892 )

♂ • incomplete penetrance of abnormal tubules either lacking germ cells or containing apoptotic spermatocytes

small testis ( J:84892 )

♂

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Fanconi anemia complementation group D2		DOID:0111083	OMIM:227646	J:84892