Phenotypes Associated with This Genotype

Genotype
MGI:2674328

• Allelic Composition: Ar^Tfm/Y
• Genetic Background: involves: STOCK Eda^Ta Atp7a^Mo-blo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

arrest of male meiosis ( J:140803 )

• spermatogenesis does not proceed beyond meiosis prophase

abnormal seminiferous tubule morphology ( J:140803 )

• Background Sensitivity: mice exhibit thickening and hyperplasia of peritubular myoid cells that is not as great as when the allele is present on a mixed NMRI and stock of origin background

secondary sex reversal ( J:140803 )

• male mice have female genitals, a blind ending vagina, inguinal testes, no scrotum and lack derivatives of the Wolffian ducts

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:140803 )

• Background Sensitivity: mice exhibit thickening and hyperplasia of peritubular myoid cells that is not as great as when the allele is present on a mixed NMRI and stock of origin background

hematopoietic system

abnormal erythropoiesis ( J:110923 )

• the percentage of TER119+ cells in the bone marrow is decreased

• however, the number of circulating TER119+ cells is not significantly different from controls

increased immature B cell number ( J:110923 )

• increase in the percentage and absolute number of B cell precursors

• however, the number of LPS responsive B cells is not increased

abnormal bone marrow cell number ( J:110923 )

• the number of MAC-1+ cells in the bone marrow is decreased

• the percentage of TER119+ cells in the bone marrow is decreased

abnormal myeloid leukocyte morphology ( J:110923 )

• the number of MAC-1+ cells in the bone marrow is decreased

• however, the number of circulating MAC-1+ cells is not significantly different from controls

immune system

increased immature B cell number ( J:110923 )

• increase in the percentage and absolute number of B cell precursors

• however, the number of LPS responsive B cells is not increased

abnormal myeloid leukocyte morphology ( J:110923 )

• the number of MAC-1+ cells in the bone marrow is decreased

• however, the number of circulating MAC-1+ cells is not significantly different from controls

cellular

arrest of male meiosis ( J:140803 )

• spermatogenesis does not proceed beyond meiosis prophase

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
androgen insensitivity syndrome		DOID:4674	OMIM:300068	J:140803