Phenotypes Associated with This Genotype

Genotype
MGI:2675118

• Allelic Composition: Rasgrp1^lag/Rasgrp1^lag
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

enlarged spleen ( J:85189 )

abnormal positive T cell selection ( J:85189 )

• defects in positive selection

increased B cell number ( J:85189 )

• activated B cells accumulate but show normal proliferation and apoptosis

increased T cell number ( J:85189 )

• CD4⁺ T cells accumulated in the lymphoid tissues of older mice

increased IgG level ( J:85189 )

• increased serum levels observed in aged mice

• deposits detected in glomeruli

abnormal T cell physiology ( J:85189 )

• T cells showed reduced responses to antigen and failed to undergo activation induced cell death

decreased T cell proliferation ( J:85189 )

• T cells failed to proliferate vigorously following antigen encounter

immune system

enlarged spleen ( J:85189 )

abnormal positive T cell selection ( J:85189 )

• defects in positive selection

increased B cell number ( J:85189 )

• activated B cells accumulate but show normal proliferation and apoptosis

increased T cell number ( J:85189 )

• CD4⁺ T cells accumulated in the lymphoid tissues of older mice

increased IgG level ( J:85189 )

• increased serum levels observed in aged mice

• deposits detected in glomeruli

abnormal T cell physiology ( J:85189 )

• T cells showed reduced responses to antigen and failed to undergo activation induced cell death

decreased T cell proliferation ( J:85189 )

• T cells failed to proliferate vigorously following antigen encounter

abnormal lymph node morphology ( J:85189 )

• generalized lymphadenopathy involving the submandibular, axillary, iliac, inguinal, and mesenteric nodes

• 10-fold increases in size and cellularity were observed relative to wild-type

enlarged lymph nodes ( J:85189 )

• submandibular, axillary, iliac, inguinal, and mesenteric lymph nodes showed 10-fold increases in size and cellularity relative to wild-type

increased susceptibility to systemic lupus erythematosus ( J:85189 )

• lymphoproliferative autoimmune syndrome similar to systemic lupus erythematosus (SLE)

glomerulonephritis ( J:85189 )

• almost all mice developed a diffuse proliferative glomerulonephritis characterized by enlarged glomeruli

liver/biliary system

enlarged liver ( J:85189 )

renal/urinary system

abnormal renal glomerular capsule morphology ( J:85189 )

• reduced glomular capsule space

abnormal renal glomerulus morphology ( J:85189 )

• glomeruli were enlarged, inflamed, hyperplastic, showed thickening of the mesangium, and IgG deposits

glomerulonephritis ( J:85189 )

• almost all mice developed a diffuse proliferative glomerulonephritis characterized by enlarged glomeruli

growth/size/body

enlarged liver ( J:85189 )

enlarged spleen ( J:85189 )

cellular

decreased T cell proliferation ( J:85189 )

• T cells failed to proliferate vigorously following antigen encounter

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
systemic lupus erythematosus		DOID:9074	OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420	J:85189