Phenotypes Associated with This Genotype

Genotype
MGI:2675251

• Allelic Composition: Men1^tm1.2Zqw/Men1^tm1.2Zqw; Tg(Ins2-cre)23Herr/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased insulinoma incidence ( J:85133 )

• 41.5% of mice developed insulinomas by 6 months of age and by 10 months, 100% of mutants have advanced insulinomas (carcinomas)

endocrine/exocrine glands

pancreatic islet hyperplasia ( J:85133 )

• hyperplastic islets as early as 2 months of age, which progresses with aging

increased insulinoma incidence ( J:85133 )

• 41.5% of mice developed insulinomas by 6 months of age and by 10 months, 100% of mutants have advanced insulinomas (carcinomas)

homeostasis/metabolism

hypoglycemia ( J:85133 )

• glucose levels decreased after 8 months of agae, as tumorigenesis progressed

increased circulating insulin level ( J:85133 )

• insulin levels increased starting at 4 months of age and continued to increase with age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
multiple endocrine neoplasia type 1		DOID:10017	OMIM:131100	J:85133