Phenotypes Associated with This Genotype

Genotype
MGI:2675506

• Allelic Composition: Dnase2b^tm1Osa/Dnase2b^tm1Osa
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

cataract ( J:85215 )

• cataracts of the nucleus lentis caused by undigested DNA left in the lens

• eyeballs are of normal morphology, with well-differentiated mature lens fiber cells

abnormal eye electrophysiology ( J:85215 )

• electroretinogram recordings under dark-adapted conditions shows that responses to the light flash are severely reduced

abnormal vision ( J:85215 )

• reduction in response to light due to cataract formation

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cataract		DOID:83	OMIM:601371 OMIM:PS116200	J:85215