Phenotypes for Ndp MGI:2676253 MGI Mouse

vision/eye

abnormal retina pigmentation ( J:30902 )

• hyperpigmentation of the retinal pigment epithelium is evident within severely affectes areas

disorganized retina ganglion layer ( J:30902 )

• at 4 and 26 weeks, a general disorganization of the ganglion cell layer is observed, with some nuclei migrating into the inner plexiform layer

abnormal retina inner nuclear layer morphology ( J:30902 )

• at 4 and 26 weeks, occasional changes in the inner nuclear layers are observed

• nuclei from the inner nuclear layer are occasionally displaced into the photoreceptor layer

• even when inner nuclear and photoreceptor layers are only mildly affected, the changes within the vitreous body and the ganglion cell layer are prominent

abnormal retina outer nuclear layer morphology ( J:30902 )

• at 4 and 26 weeks, occasional changes in the outer nuclear layers are observed

• nuclei from the outer nuclear layer are occasionally displaced into the outer plexiform and the inner nuclear layer

abnormal retina outer plexiform layer morphology ( J:30902 )

• the outer plexiform layer disappears in severely affected areas

abnormal retina photoreceptor layer morphology ( J:30902 )

decreased retina photoreceptor cell number ( J:30902 )

• relocation of nuclei from the inner nuclear layers into the photoreceptor layer leads to the disappearance of photoreceptors

photoreceptor outer segment degeneration ( J:30902 )

• the outer segments of the photoreceptor cells disappear within severely affected areas

disorganized retina layers ( J:30902 )

abnormal vitreous body morphology ( J:30902 )

• at 3 weeks, 3 of 6 male hemizygotes exhibit conspicuous precipitate-like retrolental structures in the vitreous body; the variation in number and size of precipitates is age-independent

• by 10-20 weeks, all male hemizygotes show pathological signs with a variable age of onset

• in addition to the precipitates, depigmented bundles or stripes are noted in some eyes and interpreted as retinal folding or detachment

vitreous body deposition ( J:30902 )

• at 4 and 26 weeks, fibrous masses (retrolental patterns) are observed within the vitreous bodies of all eyes examined

pigmentation