Phenotypes Associated with This Genotype

Genotype
MGI:2676549

• Allelic Composition: Stk11^tm1.1Jish/Stk11⁺
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Stk11^tm1.1Jish/Stk11⁺ mice develop gastrointestinal polyps

neoplasm

increased adenoma incidence ( J:77213 )

• all mice showed gastric adenomatous polyps at 10 and 14 months of age, predominantly in the glandular stomach

increased intestinal adenoma incidence ( J:77213 )

digestive/alimentary system

increased intestinal adenoma incidence ( J:77213 )

gastric polyps ( J:77213 )

• mutants develop polyps by 10 months of age; most polyps localize at the junction of pyloric antrum and duodenum in the glandular stomach

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Peutz-Jeghers syndrome		DOID:3852	OMIM:175200	J:77213