Phenotypes Associated with This Genotype

Genotype
MGI:2677020

• Allelic Composition: Glra1^tm1Rah/Glra1⁺
• Genetic Background: involves: 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:85341 )

N • no convulsive seizures

N • no problems righting themselves when placed down on their back

N • no impairment of coordination by rotarod test

N • no disruption of pain perception by hot plate test

increased startle reflex ( J:85341 )

• increased acoustic startle response

limb grasping ( J:85341 )

• displayed hind limb clenching when lifted by the tail

nervous system

abnormal channel response ( J:85341 )

• disrupted channel function

• decreased maximal response to glycine

• reduced chloride uptake

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hyperekplexia 1		DOID:0060696	OMIM:149400	J:85341