Analysis Tools
mortality/aging
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• half of the homozygous animals died within 48 hours of birth; most of the rest died within 4 weeks after birth with a few animals surviving to 3 months of age
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behavior/neurological
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• truncal ataxia with increasing severity with age, less active in walking and splayed hind limbs
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growth/size/body
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• animals are smaller than littermates
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nervous system
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• decreased number of myelinated fibers in the sciatic nerve
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