Phenotypes Associated with This Genotype

Genotype
MGI:2677677

hm5

• Allelic Composition: Lmx1b^tm1Rjo/Lmx1b^tm1Rjo
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Retarded development of the glomerular capillaries in Lmx1b^tm1Rjo/Lmx1b^tm1Rjo mice

renal/urinary system

abnormal podocyte morphology ( J:76088 )

• impaired differentiation

• retained cuboidal shape

absent podocyte foot process ( J:76088 )

• failed to form foot processes

absent podocyte slit diaphragm ( J:76088 )

• failed to form slit diaphragms

abnormal renal glomerulus basement membrane morphology ( J:76088 )

• glomerular basement membrane split

abnormal renal glomerulus morphology ( J:76088 )

• delayed development

• smaller glomerular tuft area than wild-type or heterozygous controls

• capillary network poorly developed

abnormal glomerular capillary morphology ( J:76088 )

• severely retarded outgrowth of glomerular capillaries

abnormal glomerular capillary endothelium morphology ( J:76088 )

• capillary endothelial cells are less fenestrated

absent glomerular endothelium fenestra ( J:76088 )

• reduction or even complete lack of fenestrae in the capillary endothelium

small kidney ( J:76088 )

• smaller than wild-type littermates

cardiovascular system

abnormal glomerular capillary morphology ( J:76088 )

• severely retarded outgrowth of glomerular capillaries

abnormal glomerular capillary endothelium morphology ( J:76088 )

• capillary endothelial cells are less fenestrated

absent glomerular endothelium fenestra ( J:76088 )

• reduction or even complete lack of fenestrae in the capillary endothelium