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Phenotypes Associated with This Genotype
Genotype
MGI:2677761
Allelic
Composition		 Vhltm1Lss/Vhltm1.1Lss
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vhltm1.1Lss mutation (0 available); any Vhl mutation (17 available)
Vhltm1Lss mutation (0 available); any Vhl mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased hepatic hemangioma incidence ( J:85513 )
• observed in 18% of mice between 4 and 12 months of age, putatively due to sporadic LOH
• smaller than those observed in Vhlhtm1Lss/ Vhlhtm1.1Lss;Tg(ACTB-cre)1Tes mice

reproductive system
oligozoospermia ( J:85513 )
• 2-fold reduction in sperm count relative to wild-type

liver/biliary system
increased hepatic hemangioma incidence ( J:85513 )
• observed in 18% of mice between 4 and 12 months of age, putatively due to sporadic LOH
• smaller than those observed in Vhlhtm1Lss/ Vhlhtm1.1Lss;Tg(ACTB-cre)1Tes mice

cellular
oligozoospermia ( J:85513 )
• 2-fold reduction in sperm count relative to wild-type

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
von Hippel-Lindau disease DOID:14175 OMIM:193300
 J:85513

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory