About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:2680512
Allelic
Composition
Gba1tm4Ggb/Gba1tm1Nsb
Genetic
Background
involves: 129S/SvEv * 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gba1tm1Nsb mutation (2 available); any Gba1 mutation (47 available)
Gba1tm4Ggb mutation (0 available); any Gba1 mutation (47 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• large numbers of storage cells at 3 months of age
• accumulations of glucosylceramide (4X wild-type values) at 6.5 months of age

hematopoietic system
• small numbers of storage cells at 3-4 months of age
• accumulations of glucosylceramide (4X wild-type values) at 6.5 months of age

immune system
• accumulations of glucosylceramide (4X wild-type values) at 6.5 months of age
• small numbers of storage cells at 3-4 months of age

liver/biliary system
• small numbers of storage cells at 3 months of age
• accumulations of glucosylceramide (4X wild-type values) at 6.5 months of age

respiratory system
• large numbers of storage cells at 3 months of age
• accumulations of glucosylceramide (4X wild-type values) at 6.5 months of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Gaucher's disease DOID:1926 J:86334


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
12/10/2024
MGI 6.24
The Jackson Laboratory