Analysis Tools
mortality/aging
|
• 100% mortality by 25 weeks
(J:5043)
• most die within a few weeks of weaning
(J:30772)
|
|
• some mice die within 1 week of birth
• 55% mortality within 2 weeks
|
endocrine/exocrine glands
|
• a much smaller and dorsoventrally flattened thymic rudiment is present at E14-E15
• a thymic rudiment comprised of vesicles and lacking lymphoid cells is present at P1-P2
|
small ovary
(
J:5043
)
 |
|
growth/size/body
liver/biliary system
|
• liver lobes were atrophied and covered with red scars
• variable degrees of severity, typically increasing with age at time of death
|
reproductive system
 |
• many sperm had coiled tails
|
small ovary
(
J:5043
)
|
|
|
|
|
• many females exhibited continuous dioestrus and metaoestrus phases
|
|
|
• severely reduced fertility
|
immune system
|
• a much smaller and dorsoventrally flattened thymic rudiment is present at E14-E15
• a thymic rudiment comprised of vesicles and lacking lymphoid cells is present at P1-P2
|
|
• the proportion of red to white pulp is greater than normal
• in some cases the Malpighian follicles are present but are fewer in number and smaller than in controls
|
small spleen
(
J:202296
)
|
• in some cases an unusually high number of megakaryocytes is seen in the red pulp
|
|
• virtual absence of small lymphocytes in the thymus dependent area and the post-capillary venules are often thin walled and empty
|
integument
|
• sparse hair growth around 5 weeks of age
(J:5043)
• in some mice, cephalo-caudal migration of an irregular band of short sparse hair
(J:5043)
• mice fail to grow a first coat of hair
(J:30772)
|
|
• absent at birth
|
|
• older mice show repeated growth and loss of short and wavy vibrissae
|
wavy vibrissae
(
J:5043
)
|
• older mice show repeated growth and loss of short and wavy vibrissae
|
|
• reduction in skin thickness at 3 weeks of age, corresponding to the catagen stage of normal skin
|
behavior/neurological
|
|
• longer latency during the acquisition and reversal phases in a Morris water maze
• in the extinction phase spend more time in the training quadrant and are less able to recall data from the previous day's training
• replenishing mice with T cells from wild-type mice improves performance in a Morris water maze
|
cardiovascular system
|
• in the thymus dependent area of the lymph nodes the post-capillary venules are often thin walled and empty
|
hematopoietic system
|
• a much smaller and dorsoventrally flattened thymic rudiment is present at E14-E15
• a thymic rudiment comprised of vesicles and lacking lymphoid cells is present at P1-P2
|
|
• the proportion of red to white pulp is greater than normal
• in some cases the Malpighian follicles are present but are fewer in number and smaller than in controls
|
small spleen
(
J:202296
)
|
• in some cases an unusually high number of megakaryocytes is seen in the red pulp
|
cellular
|
|
• many sperm had coiled tails
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| DiGeorge syndrome | DOID:11198 |
OMIM:188400 |
J:202300 | |
| T-cell immunodeficiency, congenital alopecia, and nail dystrophy | DOID:0060769 |
OMIM:601705 |
J:11959 | |
