Phenotypes Associated with This Genotype

Genotype
MGI:2680727

• Allelic Composition: Il4ra^tm1Tch/Il4ra^tm1Tch
• Genetic Background: involves: 129X1/SvJ * BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased T cell proliferation ( J:86215 )

• impaired Il-4 induced CD4⁺ T cell proliferation

abnormal T-helper 2 cell morphology ( J:86215 )

• decreased persistence of Th2 cells as indicated by Il-4, Il-5, and Il-13 production

• Th2 differentiation not impaired however

abnormal immune serum protein physiology ( J:86215 )

increased IgE level ( J:86215 )

• levels are substantially higher than normal

increased IgG level ( J:86215 )

• IgG1 and IgG2 levels are higher than normal in response to OVA stimulation

respiratory system inflammation ( J:86215 )

• airway hyperresponsiveness to methacholine

• eosinophilic infiltration

• goblet cell hyperplasia

respiratory system

respiratory system inflammation ( J:86215 )

• airway hyperresponsiveness to methacholine

• eosinophilic infiltration

• goblet cell hyperplasia

increased airway responsiveness ( J:86215 )

• with methacholine challenge

hematopoietic system

decreased T cell proliferation ( J:86215 )

• impaired Il-4 induced CD4⁺ T cell proliferation

abnormal T-helper 2 cell morphology ( J:86215 )

• decreased persistence of Th2 cells as indicated by Il-4, Il-5, and Il-13 production

• Th2 differentiation not impaired however

increased IgE level ( J:86215 )

• levels are substantially higher than normal

increased IgG level ( J:86215 )

• IgG1 and IgG2 levels are higher than normal in response to OVA stimulation

cellular

decreased T cell proliferation ( J:86215 )

• impaired Il-4 induced CD4⁺ T cell proliferation

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
asthma		DOID:2841	OMIM:600807	J:86215